A COMMITMENT TO RESEARCH

WHAT EXPERTS ARE SAYING


Telomere Biosciences is committed to developing products supported by the world’s latest and most advanced research in Telomere Science.

The Guiding Principle upon which Telomere Biosciences was founded in 2010 is that the science and understanding of Telomeres has advanced in a major way since the first commercial telomerase-activating supplement was launched a full 8 years ago in 2007: the Nobel Prize in Medicine was awarded in 2009 to 3 Telomere and Telomerase researchers, and literally thousands of studies by the top experts in Telomere Science, Aging, and the many now clearly identified Telomere-related health conditions, have made breakthrough advances right through the present, including the identification of multiple natural telomerase-activating compounds and many other highly important Telomere-supportive nutritional ingredients.

Perhaps most important of all, a deeper understanding of Telomere research and science now shows conclusively that there are multiple factors which have a crucial impact on Telomere length; the 3 major causes of Telomere shortening are now clearly shown to be loss of the Telomere-lengthening enzyme, Telomerase, Oxidative Stress, and Inflammation. But key research shows that levels of Homocysteine, the inflammatory ‘cytokine’ TNF-alpha, and the ‘stress-hormone’ Cortisol also significantly impact Telomere length; and that multiple points of intervention, rather than a ‘single-bullet’ approach, are required to have the greatest positive impact on Telomere length. TELO-100 is the literal product and integration of these many advances in Telomere Science 2015.



“Telomere shortness links to common disease states: cancer, pulmonary fibrosis, cardiovascular disease (including plaques, heart attacks), vascular dementia, degenerative conditions (osteoarthritis, osteoporosis), diabetes, general risk factors for chronic disease–obesity and insulin resistance.”
Elizabeth Blackburn,
Nobel Lecture 2009 & J Imm. Meth., Jan. 31, 2010




“The Nobel Prize in Physiology or Medicine 2009 is awarded jointly to Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak for the discovery of ‘how chromosomes are protected by telomeres and the enzyme telomerase.’ If the telomeres are shortened, cells age. Conversely, if telomerase activity is high, telomere length is maintained, and cellular senescence is delayed.”
The Nobel Assembly,
Oct. 5, 2009




TELO-100 RESEARCH & CLAIMS SUPPORT


Product Overview

TELO-100 is the first and only integrated “complex” of 18 pro-Telomere nutritional ingredients, including multiple natural Telomerase-activators, to attack All major causes of Telomere shortening:

# of Ingredients Targeting Telomerase

 NO*TNF-alphaHomocysteineCortisolOxidative StressInflammation
Competitive Telomerase Activator 1
TELO-100 9 8 12 5 4 18 14


  • All 18 ingredients in TELO-100 have multiple methods of action which positively impact Telomere length
  • *Nitric Oxide (NO) is also a documented Telomerase Activator [Geron Corp.]
Summary of Human Clinical Research


Several effective Telomere length and telomerase-activating nutritional compounds have now been discovered, and the first commercial telomerase-activator, a single-compound launched in 2007, while described by the authors as a “moderate” telomerase-activator that “increased telomerase in human cells in culture,” has still shown important benefits in humans when combined with other pro-Telomere nutritional ingredients: [As reported by Drs. Calvin Harley, Bill Andrews, Maria Blasco, et.al., in Rejuvenation Research September 2010, a Dr. Bill Andrews Presentation to the Age Management Medicine Group on 3 November 2012, and a Calvin Harley, et.al. study published in Rejuvenation Research June 2013: based on the results of the first 12 months in human subjects of: "PattonProtocol-1…composed of a natural product-derived telomerase activator (TA-65), a [separate] dietary supplement pack, laboratory testing, and physician counseling.”

[Source: C. Harley 2013]


It is important to note that the additional ‘dietary supplement pack*’ was composed of multiple Anti-Oxidant, Anti-Inflammatory, and other Telomere-supportive ingredients, as are combined and integrated into the single-product TELO-100, along with TELO-100’s multiple natural product-derived telomerase-activators.

[*Supplement Facts Panel Source: C. Harley, B. Andrews 2010]


"As discussed earlier, it is important to note that we cannot determine the contribution of any single component of the PattonProtocol-1 to the observed changes.” “These data suggest that PattonProtocol-1 (TA-65 in combination with other supplements and physician counseling), improves health and may reduce risk of morbidity and mortality.”

[Source: C. Harley 2013]
Substantiation & Claims Support

Here is an Overview of the Peer-Reviewed Scientific Research Supporting TELO-100. For a complete overiew of our scientific research please contact us at info@telomerebiosciences.com.  

  • Human Clinical Research for a Telomerase-activating Compound used in Combination with a Separate “Dietary Supplement Pack” of Multiple Anti-Oxidant, Anti-Inflammatory, and other Telomere-supportive Nutritional Ingredients.
    [References 1, 2]
  • The 10 Natural Compounds in TELO-100 and T-Activator 150TM which are Documented to Activate the Telomere-Lengthening Enzyme, Telomerase
    [References 3,4, 30-67]
  • The Impact of Oxidative Stress on Telomere Length & Telomerase Activity, and the 18 Ingredients in TELO-100 which help Reduce Oxidative Stress
    [References 5-7, 68-121]
  • The Impact of Inflammation on Telomere Length & Telomerase Activity, and the 14 Ingredients in TELO-100 which help Reduce Inflammation
    [References 8,9, 122-161]
  • The Impact of the Inflammatory ‘cytokine’ TNF-alpha on Telomere Length & Telomerase Activity, & the 12 Ingredients in TELO-100 which help Maintain Healthy Levels of TNF-alpha
    [References 10, 11, 162-184]
  • The Impact of Homocysteine on Telomere Length & Telomerase Activity, and the 5 Ingredients in TELO-100 which help Maintain Healthy Levels of Homocysteine
    [References 12, 13, 185-202]
  • The Impact of Cortisol on Telomere Length & Telomerase Activity, and the 4 Ingredients in TELO-100 which help Maintain Healthy Levels of Cortisol
    [References 14, 203-208]
  • The Major Impact of Telomeres and Telomerase on Adult Stem Cell Health and Function
    [References 15-20]
  • The Major Impact of Telomeres and Telomerase on Mitochondrial Health and Function
    [References 21-24]
  • The Impact of Telomeres and Telomerase on Skin Health and Skin Aging
    [References 25-29]


TELO-20 FOR DOGS RESEARCH & CLAIMS SUPPORT


Product Overview

TELO-20 for Dogs is the First and Only Integrated “Complex” of 8 Pro-Telomere Nutritional Ingredients for Dogs, including 8 Natural Telomerase-Activators, Targeting All 3 Major Causes of Telomere Shortening , just as TELO-100 Uniquely does in Humans; Telomere research through 2015 clearly demonstrates that telomerase activation alone is just not sufficient to have maximum positive impact on Telomere Length:

# of Ingredients Targeting:Telomerase ActivationOxidative StressInflammation
TELO-20 for Dogs 8 8 8


TELO-20 for Dogs, in an exclusive, proprietary blend, uses 8 of the exact same natural ingredients as are in our human supplement, TELO-100 with T-Activator 150; your dog deserves only the highest-quality, highest-grade natural ingredients, just as humans do, to promote their health, wellness, healthy aging, and longevity

  • All ingredients are commonly and safely used in both human and canine supplements.
  • Manufactured in the U.S.
  • And dogs love the taste of these easily chewable tablets!
Summary of Research

Canine Telomeres work almost exactly as human Telomeres do and play the same vital role in canine aging, age-related conditions, longevity, and mortality. [References 1-5, 7.]

Telomeres play a key role in canine life span [References 1, 2, 7, 10-13.]

“Telomere Length is a strong predictor of average life span among 15 different dog breeds, consistent with Telomeres playing a role in life span determination.” [1]
The study shows “considerably longer life spans of dog breeds with longer telomeres”: e.g. breeds with relatively longer Telomeres, including Labrador retrievers, Beagles, Golden retrievers, and Miniature poodles, live on average substantially longer than breeds with shorter Telomeres. [1]
“Dogs lose Telomeric DNA 10-fold faster than humans” as they age, so natural nutritional intervention to positively impact the Telomere lengths of dogs is every bit as crucial to health, healthy aging, and longevity, as it is in humans. [1-5, 7-14.]

Telomere length & telomerase activity play a central role in maintaining the health, regenerative capacity, and functional lifespan of the body's Stem Cells, which regenerate cells and tissues in humans and in dogs, and are therefore crucial to health, aging, and longevity in both humans and dogs. [References 3, 4, 10, 13, 15, 16.]

Research in humans shows that a combination of natural product derived nutritional ingredients, as are uniquely combined in TELO-20 for Dogs, targeting telomerase activation, oxidative stress, and inflammation, can produce very positive health-maintenance benefits to: heart and circulatory health, metabolic health (e.g. blood glucose levels and insulin resistance), bone health, and immune health. And given the similarity of biological systems, including Telomeres and Stem Cells, research supports the same benefits to be expected in dogs. [References 3, 4, 10, 13, 15, 16.]

Key Scientific References


  1. "Telomere Length Correlates with Life Span of Dog Breeds," Cell Reports, Dec. 2012; LJ Fick, et.al.
  2. "Telomere Lengths in Dogs Decrease with Increasing Age," The Journal of Nutrition, 2002; TP McKevitt, et. al.
  3. "Telomere Lengths and Telomerase Activity in Dog Tissues: A Potential Model System to Study Human Telomere and Telomerase Biology," Nature Publishing Group, 2001; L Nasir, et.al.
  4. "Telomerase Activity Modification with Resveratrol in Canine Adipose-derived Mesenchymal Stem Cells," Reproductive Fertility Development, Dec. 2013; GA Kim, et. al.
  5. "A Model of Canine Leukocyte Telomere Dynamics," Aging Cell, 2011; A. Aviv, et. al.
  6. "An Introduction to the Clinical Use of Nutraceutical and Botanical Therapies in the Small Animal Practice," Lecture to the Colorado Veterinary Medical Association Annual Conference, 2011; RJ Silver, DVM.
  7. "Aging and Short Telomeres" [Section on Pets and Dog Telomeres], Presentation to the American Association of Anti-Aging Medicine, Dec. 2013; Dr. Bill Andrews.
  8. “A Natural Product Telomerase Activator as Part of a Health Maintenance Program,” Rejuvenation Research, September 2010; C. Harley, M. Blasco, B. Andrews, et.al.
  9. “A Natural Product Telomerase Activator as Part of a Health Maintenance Program: Metabolic & Cardiovascular Response,” Rejuvenation Research, June 29, 2013; C. Harley, J. Raffaele, et.al.,
  10. “Potential of Telomerase Activation in Extending Health Span and Longevity,” Current Opinions Cellular Biology, December 2012: M. Blasco, et.al.
  11. “Extension of Cell Life Span Using Exogenous Telomerase,” Methods Mol. Biology, 2007; M. Kang, et.al.
  12. Telomerase Activation: a Potential Key Modulator for Human Healthspan and Longevity,” Aging Research Review, May 2014; V. Boccardi, et.al
  13. “Telomerase Reactivation Reverses Tissue Degeneration in Aged Telomerase-deficient Mice,” Nature, November 2010; R.A. DePinho, et.al.
  14. “Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life,” Journal of Gerontology, 2009; Elizabeth Blackburn, R. Cawthon, et.al.
  15. “Telomere Length, Stem Cells and Aging,” Nat Chem Biol., October 2007; and “The Role of Telomeres and Telomerase in Stem Cell Aging,” FEBS Letters, September 2010; Maria A. Blasco et.al.
  16. “Telomerase Reverses Epidermal Hair Follicle Stem Cell Defects and Loss of Long-term Survival Associated with Critically Short Telomeres,” Journal of Cell Biology, October 22, 2007; M.A. Blasco, et.al.
  17. “The Role of Telomeres in the Ageing of Human Skin,” Exp Dermatol, April 2011; E.M. Buckingham, A.J. Klingelhutz.